Antihypertensive effect of auraptene, a monoterpene coumarin from the genus Citrus, upon chronic administration
Identifieur interne : 000790 ( Main/Exploration ); précédent : 000789; suivant : 000791Antihypertensive effect of auraptene, a monoterpene coumarin from the genus Citrus, upon chronic administration
Auteurs : Bibi Marjan Razavi [Iran] ; Ebrahim Arasteh [Iran] ; Mohsen Imenshahidi [Iran] ; Mehrdad Iranshahi [Iran]Source :
- Iranian Journal of Basic Medical Sciences [ 2008-3866 ] ; 2015.
Abstract
Auraptene, a monoterpene coumarin from
Five weeks administration of auraptene (2, 4, 8 and 16 mg/kg/day) and nifedipine (0.25, 0.5, 1, 2 and 4 mg/kg/day) in different groups of normotensive and hypertensive rats (at the end of 3 weeks treatment by DOCA salt) was carried out and their effects on mean systolic blood pressure (MSBP) and mean heart rate (MHR) were evaluated using tail cuff method.
Our results indicated that chronic administration of auraptene (2, 4, 8 and 16 mg/kg/day) significantly reduced the MSBP in DOCA salt treated rats in a dose and time dependent manner. The percent of decreases in MSBP levels by the highest dose of auraptene (16 mg/kg) at the end of 4 th to 8 th weeks, were 7.00%, 10.78%, 16.07%, 21.28% and 27.54% respectively (P<0.001). Moreover the antihypertensive effect of auraptene was less than nifedipine (ED50 value of nifedipine = 0.7 mg/kg at 8th week and ED50 value of auraptene = 5.64 mg/kg at 8 week).
Auraptene considerably reduced MSBP in hypertensive rats, but not in normotensive (normal saline treated) rats. The results of MHR measurement showed that the increase in MHR was not significant in comparison with DOCA treated rats.
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PubMed: 25810889
PubMed Central: 4366726
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xml:lang="fr">Iran</country><wicri:regionArea>Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author><author><name sortKey="Arasteh, Ebrahim" sort="Arasteh, Ebrahim" uniqKey="Arasteh E" first="Ebrahim" last="Arasteh">Ebrahim Arasteh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author><author><name sortKey="Imenshahidi, Mohsen" sort="Imenshahidi, Mohsen" uniqKey="Imenshahidi M" first="Mohsen" last="Imenshahidi">Mohsen Imenshahidi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author><author><name sortKey="Iranshahi, Mehrdad" sort="Iranshahi, Mehrdad" uniqKey="Iranshahi M" first="Mehrdad" last="Iranshahi">Mehrdad Iranshahi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25810889</idno><idno type="pmc">4366726</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366726</idno><idno type="RBID">PMC:4366726</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000F96</idno><idno type="wicri:Area/Pmc/Curation">000F95</idno><idno type="wicri:Area/Pmc/Checkpoint">000607</idno><idno type="wicri:Area/Ncbi/Merge">001A56</idno><idno type="wicri:Area/Ncbi/Curation">001A56</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A56</idno><idno type="wicri:doubleKey">2008-3866:2015:Razavi B:antihypertensive:effect:of</idno><idno type="wicri:Area/Main/Merge">000790</idno><idno type="wicri:Area/Main/Curation">000790</idno><idno type="wicri:Area/Main/Exploration">000790</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antihypertensive effect of auraptene, a monoterpene coumarin from the genus <italic>Citrus</italic>, upon chronic administration</title><author><name sortKey="Razavi, Bibi Marjan" sort="Razavi, Bibi Marjan" uniqKey="Razavi B" first="Bibi Marjan" last="Razavi">Bibi Marjan Razavi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author><author><name sortKey="Arasteh, Ebrahim" sort="Arasteh, Ebrahim" uniqKey="Arasteh E" first="Ebrahim" last="Arasteh">Ebrahim Arasteh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author><author><name sortKey="Imenshahidi, Mohsen" sort="Imenshahidi, Mohsen" uniqKey="Imenshahidi M" first="Mohsen" last="Imenshahidi">Mohsen Imenshahidi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author><author><name sortKey="Iranshahi, Mehrdad" sort="Iranshahi, Mehrdad" uniqKey="Iranshahi M" first="Mehrdad" last="Iranshahi">Mehrdad Iranshahi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author></analytic><series><title level="j">Iranian Journal of Basic Medical Sciences</title><idno type="ISSN">2008-3866</idno><idno type="eISSN">2008-3874</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Objective(s):</title><p>Auraptene, a monoterpene coumarin from <italic>Citrus</italic> species, exhibits cardioprotective effects. In this study, the effects of auraptene administration were investigated on blood pressure of normotensive and desoxycorticosterone acetate (DOCA) salt induced hypertensive rats.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Five weeks administration of auraptene (2, 4, 8 and 16 mg/kg/day) and nifedipine (0.25, 0.5, 1, 2 and 4 mg/kg/day) in different groups of normotensive and hypertensive rats (at the end of 3 weeks treatment by DOCA salt) was carried out and their effects on mean systolic blood pressure (MSBP) and mean heart rate (MHR) were evaluated using tail cuff method.</p></sec><sec id="st3"><title>Results:</title><p>Our results indicated that chronic administration of auraptene (2, 4, 8 and 16 mg/kg/day) significantly reduced the MSBP in DOCA salt treated rats in a dose and time dependent manner. The percent of decreases in MSBP levels by the highest dose of auraptene (16 mg/kg) at the end of 4 <sup>th</sup> to 8 <sup>th</sup> weeks, were 7.00%, 10.78%, 16.07%, 21.28% and 27.54% respectively (P<0.001). Moreover the antihypertensive effect of auraptene was less than nifedipine (ED<sub>50</sub> value of nifedipine = 0.7 mg/kg at 8<sup>th</sup> week and ED<sub>50</sub> value of auraptene = 5.64 mg/kg at 8 week).</p></sec><sec id="st4"><title>Conclusion:</title><p>Auraptene considerably reduced MSBP in hypertensive rats, but not in normotensive (normal saline treated) rats. 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sortKey="Arasteh, Ebrahim" sort="Arasteh, Ebrahim" uniqKey="Arasteh E" first="Ebrahim" last="Arasteh">Ebrahim Arasteh</name><name sortKey="Imenshahidi, Mohsen" sort="Imenshahidi, Mohsen" uniqKey="Imenshahidi M" first="Mohsen" last="Imenshahidi">Mohsen Imenshahidi</name><name sortKey="Iranshahi, Mehrdad" sort="Iranshahi, Mehrdad" uniqKey="Iranshahi M" first="Mehrdad" last="Iranshahi">Mehrdad Iranshahi</name><name sortKey="Razavi, Bibi Marjan" sort="Razavi, Bibi Marjan" uniqKey="Razavi B" first="Bibi Marjan" last="Razavi">Bibi Marjan Razavi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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